CovidStanfordV1, Main, Exploration, bibRecord, 000767

COVID-19 PICU guidelines: for high- and limited-resource settings.

Identifieur interne : 000767 ( Main/Exploration ); précédent : 000766; suivant : 000768

COVID-19 PICU guidelines: for high- and limited-resource settings.

Auteurs : Saraswati Kache [États-Unis] ; Mohammod Jobayer Chisti [Bangladesh] ; Felicity Gumbo [Zimbabwe] ; Ezekiel Mupere [Ouganda] ; Xia Zhi [République populaire de Chine] ; Karthi Nallasamy [Inde] ; Satoshi Nakagawa [Japon] ; Jan Hau Lee [Singapour] ; Matteo Di Nardo [Italie] ; Pedro De La Oliva [Espagne] ; Chhavi Katyal [États-Unis] ; Kanwaljeet J S. Anand [États-Unis] ; Daniela Carla De Souza [Brésil] ; Vanessa Soares Lanziotti [Brésil] ; Joseph Carcillo [États-Unis]

Source :

Pediatric research [ 1530-0447 ] ; 2020.

RBID : pubmed:32634818

Descripteurs français

English descriptors

KwdEn :
- Adolescent (MeSH), Africa (epidemiology), Americas (epidemiology), Antiviral Agents (therapeutic use), Asia (epidemiology), Betacoronavirus (MeSH), COVID-19 (MeSH), Cardiopulmonary Resuscitation (methods), Cardiopulmonary Resuscitation (standards), Child (MeSH), Child, Preschool (MeSH), Combined Modality Therapy (MeSH), Comorbidity (MeSH), Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Coronavirus Infections (therapy), Critical Care (methods), Critical Care (standards), Cross Infection (prevention & control), Europe (epidemiology), Extracorporeal Membrane Oxygenation (standards), Female (MeSH), Humans (MeSH), Infant (MeSH), Infant, Newborn (MeSH), Infection Control (methods), Infection Control (standards), Intensive Care Units, Pediatric (standards), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (epidemiology), Pneumonia, Viral (therapy), Respiration, Artificial (standards), Respiratory Distress Syndrome (etiology), Respiratory Distress Syndrome (therapy), SARS-CoV-2 (MeSH), Shock (etiology), Shock (therapy), Systemic Inflammatory Response Syndrome (epidemiology), Systemic Inflammatory Response Syndrome (therapy).
MESH :
- chemical , therapeutic use : Antiviral Agents.
- geographic , epidemiology : Africa, Americas, Asia, Europe.
- complications : Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Pneumonia, Viral, Systemic Inflammatory Response Syndrome.
- etiology : Respiratory Distress Syndrome, Shock.
- methods : Cardiopulmonary Resuscitation, Critical Care, Infection Control.
- prevention & control : Cross Infection.
- standards : Cardiopulmonary Resuscitation, Critical Care, Extracorporeal Membrane Oxygenation, Infection Control, Intensive Care Units, Pediatric, Respiration, Artificial.
- therapy : Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome, Shock, Systemic Inflammatory Response Syndrome.
- Adolescent, Betacoronavirus, COVID-19, Child, Child, Preschool, Combined Modality Therapy, Comorbidity, Female, Humans, Infant, Infant, Newborn, Male, Pandemics, SARS-CoV-2.

Abstract

BACKGROUND

Fewer children than adults have been affected by the COVID-19 pandemic, and the clinical manifestations are distinct from those of adults. Some children particularly those with acute or chronic co-morbidities are likely to develop critical illness. Recently, a multisystem inflammatory syndrome (MIS-C) has been described in children with some of these patients requiring care in the pediatric ICU.

METHODS

An international collaboration was formed to review the available evidence and develop evidence-based guidelines for the care of critically ill children with SARS-CoV-2 infection. Where the evidence was lacking, those gaps were replaced with consensus-based guidelines.

RESULTS

This process has generated 44 recommendations related to pediatric COVID-19 patients presenting with respiratory distress or failure, sepsis or septic shock, cardiopulmonary arrest, MIS-C, those requiring adjuvant therapies, or ECMO. Evidence to explain the milder disease patterns in children and the potential to use repurposed anti-viral drugs, anti-inflammatory or anti-thrombotic therapies are also described.

CONCLUSION

Brief summaries of pediatric SARS-CoV-2 infection in different regions of the world are included since few registries are capturing this data globally. These guidelines seek to harmonize the standards and strategies for intensive care that critically ill children with COVID-19 receive across the world.

IMPACT

At the time of publication, this is the latest evidence for managing critically ill children infected with SARS-CoV-2. Referring to these guidelines can decrease the morbidity and potentially the mortality of children effected by COVID-19 and its sequalae. These guidelines can be adapted to both high- and limited-resource settings.

DOI: 10.1038/s41390-020-1053-9
PubMed: 32634818
PubMed Central: PMC7577838

Affiliations:

Bangladesh, Brésil, Espagne, Inde, Italie, Japon, Ouganda, République populaire de Chine, Singapour, Zimbabwe, États-Unis
Californie, Communauté de Madrid, Latium, Pennsylvanie, Région de Kantō, État de New York, État de São Paulo
Madrid, Rome, São Paulo, Tokyo

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000531
to stream Main, to step Curation: 000531

Le document en format XML

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<author><name sortKey="De La Oliva, Pedro" sort="De La Oliva, Pedro" uniqKey="De La Oliva P" first="Pedro" last="De La Oliva">Pedro De La Oliva</name>
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<author><name sortKey="Carcillo, Joseph" sort="Carcillo, Joseph" uniqKey="Carcillo J" first="Joseph" last="Carcillo">Joseph Carcillo</name>
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<author><name sortKey="Mupere, Ezekiel" sort="Mupere, Ezekiel" uniqKey="Mupere E" first="Ezekiel" last="Mupere">Ezekiel Mupere</name>
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<author><name sortKey="Zhi, Xia" sort="Zhi, Xia" uniqKey="Zhi X" first="Xia" last="Zhi">Xia Zhi</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Nallasamy, Karthi" sort="Nallasamy, Karthi" uniqKey="Nallasamy K" first="Karthi" last="Nallasamy">Karthi Nallasamy</name>
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<country xml:lang="fr">Inde</country>
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<author><name sortKey="Nakagawa, Satoshi" sort="Nakagawa, Satoshi" uniqKey="Nakagawa S" first="Satoshi" last="Nakagawa">Satoshi Nakagawa</name>
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<author><name sortKey="Lee, Jan Hau" sort="Lee, Jan Hau" uniqKey="Lee J" first="Jan Hau" last="Lee">Jan Hau Lee</name>
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<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Children's Intensive Care Unit, KK Women's and Children's Hospital, Duke-NUS Medical School, Singapore</wicri:regionArea>
<wicri:noRegion>Singapore</wicri:noRegion>
</affiliation>
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<author><name sortKey="Di Nardo, Matteo" sort="Di Nardo, Matteo" uniqKey="Di Nardo M" first="Matteo" last="Di Nardo">Matteo Di Nardo</name>
<affiliation wicri:level="3"><nlm:affiliation>Pediatric Intensive Care Unit, Children's Hospital Bambino Gesù, Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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</affiliation>
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<author><name sortKey="De La Oliva, Pedro" sort="De La Oliva, Pedro" uniqKey="De La Oliva P" first="Pedro" last="De La Oliva">Pedro De La Oliva</name>
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<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Katyal, Chhavi" sort="Katyal, Chhavi" uniqKey="Katyal C" first="Chhavi" last="Katyal">Chhavi Katyal</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pediatric Critical Care Medicine, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
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<author><name sortKey="Anand, Kanwaljeet J S" sort="Anand, Kanwaljeet J S" uniqKey="Anand K" first="Kanwaljeet J S" last="Anand">Kanwaljeet J S. Anand</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
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<author><name sortKey="De Souza, Daniela Carla" sort="De Souza, Daniela Carla" uniqKey="De Souza D" first="Daniela Carla" last="De Souza">Daniela Carla De Souza</name>
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<author><name sortKey="Lanziotti, Vanessa Soares" sort="Lanziotti, Vanessa Soares" uniqKey="Lanziotti V" first="Vanessa Soares" last="Lanziotti">Vanessa Soares Lanziotti</name>
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</affiliation>
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<author><name sortKey="Carcillo, Joseph" sort="Carcillo, Joseph" uniqKey="Carcillo J" first="Joseph" last="Carcillo">Joseph Carcillo</name>
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<country xml:lang="fr">États-Unis</country>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Africa (epidemiology)</term>
<term>Americas (epidemiology)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Asia (epidemiology)</term>
<term>Betacoronavirus (MeSH)</term>
<term>COVID-19 (MeSH)</term>
<term>Cardiopulmonary Resuscitation (methods)</term>
<term>Cardiopulmonary Resuscitation (standards)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Combined Modality Therapy (MeSH)</term>
<term>Comorbidity (MeSH)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Critical Care (methods)</term>
<term>Critical Care (standards)</term>
<term>Cross Infection (prevention & control)</term>
<term>Europe (epidemiology)</term>
<term>Extracorporeal Membrane Oxygenation (standards)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Infant, Newborn (MeSH)</term>
<term>Infection Control (methods)</term>
<term>Infection Control (standards)</term>
<term>Intensive Care Units, Pediatric (standards)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Respiration, Artificial (standards)</term>
<term>Respiratory Distress Syndrome (etiology)</term>
<term>Respiratory Distress Syndrome (therapy)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Shock (etiology)</term>
<term>Shock (therapy)</term>
<term>Systemic Inflammatory Response Syndrome (epidemiology)</term>
<term>Systemic Inflammatory Response Syndrome (therapy)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Afrique (épidémiologie)</term>
<term>Amériques (épidémiologie)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Asie (épidémiologie)</term>
<term>Association thérapeutique (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Choc (thérapie)</term>
<term>Choc (étiologie)</term>
<term>Comorbidité (MeSH)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Europe (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infection croisée (prévention et contrôle)</term>
<term>Infections à coronavirus (complications)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Mâle (MeSH)</term>
<term>Nourrisson (MeSH)</term>
<term>Nouveau-né (MeSH)</term>
<term>Oxygénation extracorporelle sur oxygénateur à membrane (normes)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (complications)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Prévention des infections (méthodes)</term>
<term>Prévention des infections (normes)</term>
<term>Réanimation cardiopulmonaire (méthodes)</term>
<term>Réanimation cardiopulmonaire (normes)</term>
<term>Soins de réanimation (méthodes)</term>
<term>Soins de réanimation (normes)</term>
<term>Syndrome de réponse inflammatoire généralisée (thérapie)</term>
<term>Syndrome de réponse inflammatoire généralisée (épidémiologie)</term>
<term>Unités de soins intensifs pédiatriques (normes)</term>
<term>Ventilation artificielle (normes)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Africa</term>
<term>Americas</term>
<term>Asia</term>
<term>Europe</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Systemic Inflammatory Response Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Respiratory Distress Syndrome</term>
<term>Shock</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cardiopulmonary Resuscitation</term>
<term>Critical Care</term>
<term>Infection Control</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Prévention des infections</term>
<term>Réanimation cardiopulmonaire</term>
<term>Soins de réanimation</term>
</keywords>
<keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Oxygénation extracorporelle sur oxygénateur à membrane</term>
<term>Prévention des infections</term>
<term>Réanimation cardiopulmonaire</term>
<term>Soins de réanimation</term>
<term>Unités de soins intensifs pédiatriques</term>
<term>Ventilation artificielle</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cross Infection</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Infection croisée</term>
</keywords>
<keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Cardiopulmonary Resuscitation</term>
<term>Critical Care</term>
<term>Extracorporeal Membrane Oxygenation</term>
<term>Infection Control</term>
<term>Intensive Care Units, Pediatric</term>
<term>Respiration, Artificial</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Distress Syndrome</term>
<term>Shock</term>
<term>Systemic Inflammatory Response Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Choc</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Syndrome de réponse inflammatoire généralisée</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Afrique</term>
<term>Amériques</term>
<term>Asie</term>
<term>Europe</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Syndrome de réponse inflammatoire généralisée</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Choc</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Betacoronavirus</term>
<term>COVID-19</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Combined Modality Therapy</term>
<term>Comorbidity</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Pandemics</term>
<term>SARS-CoV-2</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Association thérapeutique</term>
<term>Betacoronavirus</term>
<term>Comorbidité</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Pandémies</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Fewer children than adults have been affected by the COVID-19 pandemic, and the clinical manifestations are distinct from those of adults. Some children particularly those with acute or chronic co-morbidities are likely to develop critical illness. Recently, a multisystem inflammatory syndrome (MIS-C) has been described in children with some of these patients requiring care in the pediatric ICU.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>An international collaboration was formed to review the available evidence and develop evidence-based guidelines for the care of critically ill children with SARS-CoV-2 infection. Where the evidence was lacking, those gaps were replaced with consensus-based guidelines.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>This process has generated 44 recommendations related to pediatric COVID-19 patients presenting with respiratory distress or failure, sepsis or septic shock, cardiopulmonary arrest, MIS-C, those requiring adjuvant therapies, or ECMO. Evidence to explain the milder disease patterns in children and the potential to use repurposed anti-viral drugs, anti-inflammatory or anti-thrombotic therapies are also described.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Brief summaries of pediatric SARS-CoV-2 infection in different regions of the world are included since few registries are capturing this data globally. These guidelines seek to harmonize the standards and strategies for intensive care that critically ill children with COVID-19 receive across the world.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>IMPACT</b>
</p>
<p>At the time of publication, this is the latest evidence for managing critically ill children infected with SARS-CoV-2. Referring to these guidelines can decrease the morbidity and potentially the mortality of children effected by COVID-19 and its sequalae. These guidelines can be adapted to both high- and limited-resource settings.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32634818</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1530-0447</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>88</Volume>
<Issue>5</Issue>
<PubDate><Year>2020</Year>
<Month>11</Month>
</PubDate>
</JournalIssue>
<Title>Pediatric research</Title>
<ISOAbbreviation>Pediatr Res</ISOAbbreviation>
</Journal>
<ArticleTitle>COVID-19 PICU guidelines: for high- and limited-resource settings.</ArticleTitle>
<Pagination><MedlinePgn>705-716</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41390-020-1053-9</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Fewer children than adults have been affected by the COVID-19 pandemic, and the clinical manifestations are distinct from those of adults. Some children particularly those with acute or chronic co-morbidities are likely to develop critical illness. Recently, a multisystem inflammatory syndrome (MIS-C) has been described in children with some of these patients requiring care in the pediatric ICU.</AbstractText>
<AbstractText Label="METHODS">An international collaboration was formed to review the available evidence and develop evidence-based guidelines for the care of critically ill children with SARS-CoV-2 infection. Where the evidence was lacking, those gaps were replaced with consensus-based guidelines.</AbstractText>
<AbstractText Label="RESULTS">This process has generated 44 recommendations related to pediatric COVID-19 patients presenting with respiratory distress or failure, sepsis or septic shock, cardiopulmonary arrest, MIS-C, those requiring adjuvant therapies, or ECMO. Evidence to explain the milder disease patterns in children and the potential to use repurposed anti-viral drugs, anti-inflammatory or anti-thrombotic therapies are also described.</AbstractText>
<AbstractText Label="CONCLUSION">Brief summaries of pediatric SARS-CoV-2 infection in different regions of the world are included since few registries are capturing this data globally. These guidelines seek to harmonize the standards and strategies for intensive care that critically ill children with COVID-19 receive across the world.</AbstractText>
<AbstractText Label="IMPACT">At the time of publication, this is the latest evidence for managing critically ill children infected with SARS-CoV-2. Referring to these guidelines can decrease the morbidity and potentially the mortality of children effected by COVID-19 and its sequalae. These guidelines can be adapted to both high- and limited-resource settings.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kache</LastName>
<ForeName>Saraswati</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA. skache@stanford.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chisti</LastName>
<ForeName>Mohammod Jobayer</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit and Clinical Research, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gumbo</LastName>
<ForeName>Felicity</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics and Child Health, College of Health Sciences University of Zimbabwe, Harare, Zimbabwe.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mupere</LastName>
<ForeName>Ezekiel</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics and Child Health, School of Medicine College of Health Sciences, Makerere University, Kampala, Uganda.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhi</LastName>
<ForeName>Xia</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Pediatric Intensive Care Unit, Maternal and Child Health Hospital of Hubei Province, Wuhan City, Hubei Province, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nallasamy</LastName>
<ForeName>Karthi</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nakagawa</LastName>
<ForeName>Satoshi</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Critical Care Medicine, National Center for Child Health & Development, Tokyo, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Jan Hau</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Children's Intensive Care Unit, KK Women's and Children's Hospital, Duke-NUS Medical School, Singapore, Singapore.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Di Nardo</LastName>
<ForeName>Matteo</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Pediatric Intensive Care Unit, Children's Hospital Bambino Gesù, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de la Oliva</LastName>
<ForeName>Pedro</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Pediatric Intensive Care Department, Hospital Universitario La Paz, Department of Pediatrics Medical School, Universidad Autónoma de Madrid, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Katyal</LastName>
<ForeName>Chhavi</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Pediatric Critical Care Medicine, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anand</LastName>
<ForeName>Kanwaljeet J S</ForeName>
<Initials>KJS</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Souza</LastName>
<ForeName>Daniela Carla</ForeName>
<Initials>DC</Initials>
<AffiliationInfo><Affiliation>Pediatric Intensive Care Unit, University of São Paulo & Hospital Sírio Libanês-, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lanziotti</LastName>
<ForeName>Vanessa Soares</ForeName>
<Initials>VS</Initials>
<AffiliationInfo><Affiliation>Pediatric Intensive Care Unit & Research and Education Division/Maternal and Child Health Postgraduate Program, Federal University of Rio De Janeiro, Rio De Janeiro, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carcillo</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Departments of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D017065">Practice Guideline</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>07</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Pediatr Res</MedlineTA>
<NlmUniqueID>0100714</NlmUniqueID>
<ISSNLinking>0031-3998</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName>
<SupplMeshName Type="Disease" UI="C000705967">pediatric multisystem inflammatory disease, COVID-19 related</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000349" MajorTopicYN="N" Type="Geographic">Africa</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000569" MajorTopicYN="N" Type="Geographic">Americas</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001208" MajorTopicYN="N" Type="Geographic">Asia</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016887" MajorTopicYN="N">Cardiopulmonary Resuscitation</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003422" MajorTopicYN="N">Critical Care</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003428" MajorTopicYN="N">Cross Infection</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015199" MajorTopicYN="N">Extracorporeal Membrane Oxygenation</DescriptorName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017053" MajorTopicYN="N">Infection Control</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015278" MajorTopicYN="N">Intensive Care Units, Pediatric</DescriptorName>
<QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012769" MajorTopicYN="N">Shock</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018746" MajorTopicYN="N">Systemic Inflammatory Response Syndrome</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
</MeshHeadingList>
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COVID-19 PICU guidelines: for high- and limited-resource settings.

COVID-19 PICU guidelines: for high- and limited-resource settings.

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